The Blues travel to St Petersburg on Wednesday (KO 5.45 pm UK time).
Chalobah, Kante, Jorginho, Chilwell are on the treatment table. Kovacic misses the game after testing positive for Covid-19.
Lukaku is not 100 percent match fit. Havertz and Alonso are injury doubts.
Goalkeeper Stanislav Kritsyuk is unavailable through injury. Dmitriy Chistyakov is suspended after seeing red against Malmo.
We believe Tuchel will rotate his squad a little bit, introducing Pulisic, Werner, Barkley, and Hudson-Odoi from the off.
Chelsea have already qualified for the Round of 16. But they need a victory to guarantee a top spot in the group.
The Blues can afford to draw in St Petersburg if Juventus fail to beat Malmo — Tuchel’s side would top the table.
Chelsea can finish first even if they lose to Zenit, but they would need Malmo to defeat Juventus.
Zenit have secured a third-placed finish so the result against Chelsea will have no bearing on their position in the table.
Full Chelsea’s 20-Man Squad
Chelsea have confirmed that 20 players have traveled to St Petersburg:
Kepa Arrizabalaga, Antonio Rudiger, Marcos Alonso, Andreas Christensen, Thiago Silva, Romelu Lukaku, Christian Pulisic, Timo Werner, Ruben Loftus-Cheek, Marcus Bettinelli, Edouard Mendy, Saul Niguez, Ross Barkley, Mason Mount, Callum Hudson-Odoi, Hakim Ziyech, Reece James, Cesar Azpilicueta, Kai Havertz, Malang Sarr.
Jorginho, Ben Chilwell, N’Golo Kante, and Trevoh Chalobah have not made the squad.